Examines the relationship between disease and health inequity. Reviews historical and current patterns in outbreaks, epidemics, and pandemics whose trajectories were shaped not only by viruses and bacteria but also by histories, events, populations, social determinants, inequitable distributions of power, climate change, and social capital. Unpacks how diseases have radically transformed the landscape of how we work and play, driven innovations in vaccine development, and exerted a powerful influence on politics. Discusses how climate change has produced new weather patterns, and how insects as disease vectors have appeared in new areas, putting human populations at increased risk. Offers students an opportunity to build skills and conceptual links between infectious disease and social determinants of health that are critical in averting epidemics.