Presents an in-depth, case-driven examination of RNA therapeutics and the nanodrug delivery systems that support them. Introduces strategies for modulating endogenous RNA pathways and delivering exogenous RNA payloads, with attention to formulation, stabilization, and platform optimization. Integrates preclinical evidence, clinical trial data, and post-market experiences from both successful and failed therapies to emphasize the importance of design choices that impact RNA delivery, safety, potency, and efficacy. Highlights the current challenges and emerging innovations shaping next-generation RNA technologies.