BIOT 5850 — Higher-Order Structure Analytics
3 semester hoursGraduateLectureusually offered: springBostonOnlineToronto, CanadaOnlineTraditional
Offers a comprehensive look at various aspects of higher- order protein structures in biotherapeutics and their implications on biological drug design. Focuses heavily on protein aggregation, a type of HOS, and analysis of those aggregates including functional implications. Topics include a review of protein structure, protein aggregation, functional aspects, and techniques to reduce HOS using protein expression and purification strategies, protein folding in disease, macromolecular crystallography, nuclear magnetic resonance, analytical ultracentrifugation, circular dichroism, light scattering, electron spin labelling, cryo-EM, WAXS, and HDX-MS. Highlights experimental design and application to the biotechnology industry in identifying and reducing HOS.
Offering history
| Term | Sections | Enrolled | Capacity | Full | Open seats/section |
|---|---|---|---|---|---|
| Fall 2023 | 1 | 1 | 19 | 5% | 18.0 |
| Spring 2024 | 4 | 46 | 98 | 47% | 13.0 |
| Spring 2025 | 2 | 28 | 50 | 56% | 11.0 |
| Spring 2026 | 2 | 11 | 50 | 22% | 19.5 |
Snapshots from scheduled scrapes — not live seat availability. "Full" can exceed 100% when sections over-enroll.
Meeting times
Share of recent sections by weekday: M 0% · T 0% · W 23% · Th 0% · F 0%
Common patterns: async (77% of sections), W (23% of sections) — in patterns, R means Thursday
Professors
Fall
- Ryan Clauson (100% of students) · reviews
Spring
- Ryan Clauson (76% of students) · reviews
- Sudhakaran Prabakaran (13% of students) · reviews
- Daniel Donnelly (11% of students) · reviews
Percentages are each professor's average share of the season's enrolled students in recent terms.
Links
Official catalog (BIOT course descriptions) · Student reviews on RateMyHusky · All BIOT courses · Plan it at numap.app